Sorcs1^tm1.1Gndy
Targeted Allele Detail

Summary

• Symbol: Sorcs1^tm1.1Gndy
• Name: sortilin-related VPS10 domain containing receptor 1; targeted mutation 1.1, Samuel Gandy
• MGI ID: MGI:4836913
• Gene: Sorcs1 Location: Chr19:50131737-50667084 bp, - strand Genetic Position: Chr19, 45.05 cM, cytoband D2
• Alliance: Sorcs1^tm1.1Gndy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164876
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Hypomorph) Mutations: Insertion, Intragenic deletion Mutation details: LoxP sites flanking part of the promoter, all of exon 1, and a portion of intron 1 were introduced by homologous recombination. Cre mediated recombination removed exon 1 and the selection cassette. Mice exhibit a 50% reduction in transcript in brains. (J:164876)

Generation of the Sorcs1^tm1.1Gndy allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sorcs1 Mutation: 80 strains or lines available

References

• Original: J:164876 Lane RF, et al., Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. J Neurosci. 2010 Sep 29;30(39):13110-5
• All: 3 reference(s)