Cxcr4^tm1Yiw
Targeted Allele Detail

Summary

• Symbol: Cxcr4^tm1Yiw
• Name: C-X-C motif chemokine receptor 4; targeted mutation 1, Yoichiro Iwakura
• MGI ID: MGI:4836915
• Synonyms: Cxcr4^flox
• Gene: Cxcr4 Location: Chr1:128515936-128520030 bp, - strand Genetic Position: Chr1, 56.43 cM
• Alliance: Cxcr4^tm1Yiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164872
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was floxed and a neomycin resistant cassette was inserted 5' to the second loxP site within intron 2. (J:164872)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Cxcr4 Mutation: 46 strains or lines available

References

• Original: J:164872 Chung SH, et al., CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis. Arthritis Res Ther. 2010 Oct 12;12(5):R188
• All: 4 reference(s)