Rr177^tm1Tow
Targeted Allele Detail

Summary

• Symbol: Rr177^tm1Tow
• Name: regulatory region 177; targeted mutation 1, Timothy Townes
• MGI ID: MGI:4836920
• Synonyms: Klf1^EHS1delta, Klf1^tm1Tow
• Gene: Rr177 Location: Chr8:85627716-85628077 bp Genetic Position: Chr8, Syntenic
• Alliance: Rr177^tm1Tow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164803
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: A 50 bp sequence containing the HS1 enhancer (EHS1) upstream of Klf1 was removed. The absence of protein expression was confirmed by western blot analysis on E14.5 liver extracts. (J:164803)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr177 Mutation: 0 strains or lines available

References

• Original: J:164803 Zhou D, et al., KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching. Nat Genet. 2010 Sep;42(9):742-4
• All: 1 reference(s)