Hspa4^tm1.1Miv
Targeted Allele Detail

Summary

• Symbol: Hspa4^tm1.1Miv
• Name: heat shock protein 4; targeted mutation 1.1, Nahid F Mivechi
• MGI ID: MGI:4836945
• Synonyms: hsp110^-
• Gene: Hspa4 Location: Chr11:53150641-53191284 bp, - strand Genetic Position: Chr11, 31.91 cM
• Alliance: Hspa4^tm1.1Miv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164904
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a lacZ gene and floxed neo cassette. Cre mediated recombination removed the neo cassette. The absence of full length product and production of beta-galactosidase was confirmed by western blot analysis of brain extracts. (J:164904)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspa4 Mutation: 75 strains or lines available

References

• Original: J:164904 Eroglu B, et al., Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta. Mol Cell Biol. 2010 Oct;30(19):4626-43
• All: 2 reference(s)