Rr7^tm1.1Kio
Targeted Allele Detail

Summary

• Symbol: Rr7^tm1.1Kio
• Name: regulatory region 7; targeted mutation 1.1, Dimitris Kioussis
• MGI ID: MGI:4837102
• Synonyms: CD8/LCR (cII-III), mCD8-(hCD2-LCR)
• Gene: Rr7 Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Rr7^tm1.1Kio page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164573
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

Allele Type: Targeted (Modified regulatory region) Mutation: Insertion Mutation details: A loxP site flanked neomycin resistance gene cassette and the locus control region of human CD2 were inserted between DNase I hypersensitivity clusters cII and cIII of the CD8 locus control region. Cre-mediated recombination removed the neo cassette. (J:164573)

Generation of the Rr7^tm1.1Kio and Rr7^tm2.1Kio alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr7 Mutation: 0 strains or lines available

References

• Original: J:164573 Menzel U, et al., Replication allows inactivation of a knocked-in locus control region in inappropriate cell lineages. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16928-33
• All: 2 reference(s)