Pkd1l3^tm1.1Abek
Targeted Allele Detail

Summary

• Symbol: Pkd1l3^tm1.1Abek
• Name: polycystic kidney disease 1 like 3; targeted mutation 1.1, Keiko Abe
• MGI ID: MGI:4837113
• Gene: Pkd1l3 Location: Chr8:110340828-110399305 bp, + strand Genetic Position: Chr8, 57.14 cM, cytoband A
• Alliance: Pkd1l3^tm1.1Abek page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165309
• Parent Cell Line: EF1 (ES Cell)
• Strain of Origin: 129S/SvEv x C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 26 through 31 with an IRES, an EGFP, and a self-excising floxed neo cassette. These exons encode transmembrane domains 7 through 11. In situ hybridization confirmed the absence of transcript expression in the taste buds of the circumvallate papillae. (J:165309)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pkd1l3 Mutation: 154 strains or lines available

References

• Original: J:165309 Ishimaru Y, et al., Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae. FASEB J. 2010 Oct;24(10):4058-67
• All: 2 reference(s)