Kcnh3^tm1.1Tije
Targeted Allele Detail

Summary

• Symbol: Kcnh3^tm1.1Tije
• Name: potassium voltage-gated channel, subfamily H (eag-related), member 3; targeted mutation 1.1, Timothy Jegla
• MGI ID: MGI:4837119
• Synonyms: Kv12.2^loxP
• Gene: Kcnh3 Location: Chr15:99122742-99140698 bp, + strand Genetic Position: Chr15, 56.08 cM, cytoband F3
• Alliance: Kcnh3^tm1.1Tije page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165296
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Flp mediated recombination removed the neo cassette leaving exons 2 through 4 floxed. (J:165296)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnh3 Mutation: 42 strains or lines available

References

• Original: J:165296 Zhang X, et al., Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Nat Neurosci. 2010 Sep;13(9):1056-8
• All: 1 reference(s)