Tg(MMTV-cre)105Ayn
Transgene Detail

Summary

• Symbol: Tg(MMTV-cre)105Ayn
• Name: transgene insertion 105, Alexander Yu Nikitin
• MGI ID: MGI:4837133
• Synonyms: MMTV-Cre
• Transgene: Tg(MMTV-cre)105Ayn Location: unknown
• Alliance: Tg(MMTV-cre)105Ayn page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(MMTV-cre)105Ayn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  virus	MMTV

• Mutation details: 1.48 kb of the mouse mammary tumor virus (MMTV) long terminal repeat drives mammary epithelium-specific expression of cre. The cre expression cassette is followed by several introns of methallothionein-I (MT-I) and its polyadenylation sequence. Five lines (104A, 105, 106, 107, and 108) were generated. Cre expression in line 105 is restricted to the mammary gland. (J:165292)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	MMTV (virus) Summary of all recombinase alleles driven by MMTV.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:165292 Cheng L, et al., Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency. Oncogene. 2010 Oct 21;29(42):5700-11
• All: 1 reference(s)