Ptk2^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Ptk2^tm1.1Itl
• Name: PTK2 protein tyrosine kinase 2; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:4837147
• Synonyms: FAK^KD, FAK^R454, Ptk2^L454R, Ptk2^tm1.1Igl
• Gene: Ptk2 Location: Chr15:73076951-73295129 bp, - strand Genetic Position: Chr15, 33.94 cM
• Alliance: Ptk2^tm1.1Itl page

Embryonic lethality and vascular defects in Ptk2^tm1.1Itl/Ptk2^tm1.1Itl embryos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165360
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129S/SvEv

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Single point mutation Mutation details: Exon 21 (or exon 18 depending on transcript) was replaced with one in which an A to G point transition results in the replacement of lysine with arginine at position 454 (K454R). An FRT flanked neo cassette inserted downstream of the modified exon 21 was removed by flp mediated recombination. (J:165360)

Generation of the Ptk2^tm1.1Itl allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptk2 Mutation: 91 strains or lines available

References

• Original: J:165360 Lim ST, et al., Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem. 2010 Jul 9;285(28):21526-36
• All: 5 reference(s)