Ptk2^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Ptk2^tm1Itl
• Name: PTK2 protein tyrosine kinase 2; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:4837152
• Synonyms: FAK^R454Neo, Ptk2^tm1Igl
• Gene: Ptk2 Location: Chr15:73076951-73295129 bp, - strand Genetic Position: Chr15, 33.94 cM
• Alliance: Ptk2^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165360
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129S/SvEv

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Single point mutation Mutation details: Exon 21 was replaced with one in which an A to G point transition results in the replacement of lysine with arginine at position 454 (K454R). An FRT flanked neo cassette was inserted downstream of the modified exon. (J:165360)

Generation of the Ptk2^tm1Itl allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptk2 Mutation: 91 strains or lines available

References

• Original: J:165360 Lim ST, et al., Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem. 2010 Jul 9;285(28):21526-36
• All: 1 reference(s)