Paip2^tm1.2Nso
Targeted Allele Detail

Summary

• Symbol: Paip2^tm1.2Nso
• Name: polyadenylate-binding protein-interacting protein 2; targeted mutation 1.2, Nahum Sonenberg
• MGI ID: MGI:4837189
• Gene: Paip2 Location: Chr18:35731670-35750240 bp, + strand Genetic Position: Chr18, 19.16 cM
• Alliance: Paip2^tm1.2Nso page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165272
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination of Paip2^tm1.1Nso removed exons 2 and 3. The absence of protein expression was confirmed by western blot analysis on testes extracts. (J:165272)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Paip2 Mutation: 33 strains or lines available

References

• Original: J:165272 Yanagiya A, et al., The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice. J Clin Invest. 2010 Sep 1;120(9):3389-400
• All: 2 reference(s)