Cebpa^tm1Timc
Targeted Allele Detail

Summary

• Symbol: Cebpa^tm1Timc
• Name: CCAAT/enhancer binding protein alpha; targeted mutation 1, Nikolai A Timchenko
• MGI ID: MGI:4837200
• Synonyms: C/EBPalpha-S193D
• Gene: Cebpa Location: Chr7:34818718-34821353 bp, + strand Genetic Position: Chr7, 21.02 cM
• Alliance: Cebpa^tm1Timc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163725
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A substitution of a TC to GA in the intronless gene results in an amino acid substitution of Serine 193 to Aspartic acid (S193D). In addition, a neomycin resistant cassette was inserted 3' to the coding sequence. (J:163725)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpa Mutation: 19 strains or lines available

References

• Original: J:163725 Wang GL, et al., Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice. J Clin Invest. 2010 Jul 1;120(7):2549-62
• All: 5 reference(s)