Nfasc^tm2Bhat
Targeted Allele Detail

Summary

• Symbol: Nfasc^tm2Bhat
• Name: neurofascin; targeted mutation 2, Manzoor A Bhat
• MGI ID: MGI:4837620
• Synonyms: Nfasc^IgFlox
• Gene: Nfasc Location: Chr1:132492428-132669535 bp, - strand Genetic Position: Chr1, 57.42 cM
• Alliance: Nfasc^tm2Bhat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159621
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette followed by a loxP site was inserted into intron 10 and a second loxP site was inserted in intron 15. Exons 11 to 15, encoding Ig domains 5 and 6, are flanked by loxP sites. (J:159621)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfasc Mutation: 61 strains or lines available

References

• Original: J:159621 Thaxton C, et al., In vivo deletion of immunoglobulin domains 5 and 6 in neurofascin (Nfasc) reveals domain-specific requirements in myelinated axons. J Neurosci. 2010 Apr 7;30(14):4868-76
• All: 1 reference(s)