Rad50^tm2.2Flv
Targeted Allele Detail

Summary

• Symbol: Rad50^tm2.2Flv
• Name: RAD50 double strand break repair protein; targeted mutation 2.2, Richard A Flavell
• MGI ID: MGI:4837634
• Synonyms: LCR^-
• Gene: Rad50 Location: Chr11:53540346-53598146 bp, - strand Genetic Position: Chr11, 31.98 cM, cytoband A5-B1
• Alliance: Rad50^tm2.2Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165055
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed DNaseI hypersensitive site 6 in intron 21 and exons 22 though 24. This allele lacks the four DNaseI hypersensitive site (RHS4, RHS5, RHS6, and RHS7) that make up the CD4 locus control region (LCR). (J:165055)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rad50 Mutation: 53 strains or lines available

References

• Original: J:165055 Koh BH, et al., Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10614-9
• All: 3 reference(s)