Tg(Cryaa-NCOA6*)AD5Cve
Transgene Detail

Summary

• Symbol: Tg(Cryaa-NCOA6*)AD5Cve
• Name: transgene insertion AD5, Ales Cvekl
• MGI ID: MGI:4837697
• Synonyms: AD5, Tg (Cryaa-dnNCOA6)
• Transgene: Tg(Cryaa-NCOA6*)AD5Cve Location: unknown
• Alliance: Tg(Cryaa-NCOA6*)AD5Cve page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The mouse promoter drives lens-specific expression of a tripple FLAG-tagged cDNA encoding amino acids 849 to 929 with a nuclear localization sequence. This amino acid section is predicted to act as a dominant negative. Lines AD5 (12 to 16 copies) and AD9 (12 to 19 copies) were generated. (J:165054)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:165054 Wang WL, et al., Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis. Mol Biol Cell. 2010 Jul 15;21(14):2453-68
• All: 1 reference(s)