Fadd^tm2.1Wnt
Targeted Allele Detail

Summary

• Symbol: Fadd^tm2.1Wnt
• Name: Fas associated via death domain; targeted mutation 2.1, Astar Winoto
• MGI ID: MGI:4837702
• Synonyms: FADD^fl
• Gene: Fadd Location: Chr7:144132060-144136178 bp, - strand Genetic Position: Chr7, 88.85 cM
• Alliance: Fadd^tm2.1Wnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162312
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The loxP flanked neomycin resistance cassette was removed from Fadd^tm2Wnt by crossing with Ella Cre transgenic mice resulting in a loxP inserted between exons 1 and 2 of FADD and an additional loxP site upstream of exon 1. This is a conditional allele. (J:162312)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fadd Mutation: 18 strains or lines available

References

• Original: J:162312 Osborn SL, et al., Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13034-9
• All: 4 reference(s)