Cyp2a5^tm1Ding
Targeted Allele Detail

Summary

• Symbol: Cyp2a5^tm1Ding
• Name: cytochrome P450, family 2, subfamily a, polypeptide 5; targeted mutation 1, Xinxin Ding
• MGI ID: MGI:4837923
• Synonyms: Cyp2a5-null
• Gene: Cyp2a5 Location: Chr7:26534764-26542689 bp, + strand Genetic Position: Chr7, 15.54 cM
• Alliance: Cyp2a5^tm1Ding page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165695
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 9 was replaced with a loxP site flanked neomycin resistance gene cassette. The absence of transcript expression was confirmed by RT-PCR on olfactory mucosa, liver, lung, kidney, and testis extracts. (J:165695)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyp2a5 Mutation: 35 strains or lines available

References

• Original: J:165695 Zhou X, et al., Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model. J Pharmacol Exp Ther. 2010 Feb;332(2):578-87
• All: 13 reference(s)