Klf13^tm1Coll
Targeted Allele Detail

Summary

• Symbol: Klf13^tm1Coll
• Name: Kruppel-like transcription factor 13; targeted mutation 1, William Colledge
• MGI ID: MGI:4837928
• Synonyms: Klf13^-
• Gene: Klf13 Location: Chr7:63536099-63588663 bp, - strand Genetic Position: Chr7, 34.58 cM
• Alliance: Klf13^tm1Coll page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136545
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first intron, encoding the transactivation domain and the first of the protein's three zinc fingers, has been replaced with a neomycin resistance cassette. Reverse transcription followed by PCR (RT-PCR) of mRNA from hearts of homozygous mutant mice detects no transcripts from the targeted gene; heterozygous mice express approximately half the wild-type level of mRNA. (J:136545)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Klf13 Mutation: 47 strains or lines available

References

• Original: J:136545 Gordon AR, et al., Splenomegaly and modified erythropoiesis in KLF13-/- mice. J Biol Chem. 2008 May 2;283(18):11897-904
• All: 2 reference(s)