Cacna1b^tm2.1Dili
Targeted Allele Detail

Summary

• Symbol: Cacna1b^tm2.1Dili
• Name: calcium channel, voltage-dependent, N type, alpha 1B subunit; targeted mutation 2.1, Diane Lipscombe
• MGI ID: MGI:4838019
• Synonyms: Cacna1b^b*b
• Gene: Cacna1b Location: Chr2:24493899-24653164 bp, - strand Genetic Position: Chr2, 16.58 cM, cytoband A2
• Alliance: Cacna1b^tm2.1Dili page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165258
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Intragenic deletion
• Mutation details: Using MICER clone MHPN59f07, exon 37a was replaced with a modified exon 37b, which lacked the XhoI restriction site, and a floxed neo cassette. Cre mediated recombination removed the neo cassette. (J:165258)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1b Mutation: 104 strains or lines available

References

• Original: J:165258 Andrade A, et al., Opioid inhibition of N-type Ca2+ channels and spinal analgesia couple to alternative splicing. Nat Neurosci. 2010 Oct;13(10):1249-56
• All: 3 reference(s)