Pip5k1ctm1.2Ref
Targeted Allele Detail
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Symbol: |
Pip5k1ctm1.2Ref |
Name: |
phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma; targeted mutation 1.2, Reinhard Fassler |
MGI ID: |
MGI:4838023 |
Synonyms: |
PIPKIgamma90-, PIPKIgammadeltaE17 |
Gene: |
Pip5k1c Location: Chr10:81128797-81155807 bp, + strand Genetic Position: Chr10, 39.72 cM
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Alliance: |
Pip5k1ctm1.2Ref page
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Germline Transmission: |
Earliest citation of germline transmission:
J:164732
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Hypomorph) |
Mutation: |
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Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 17. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 17. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exon 17. The absence of the long protein isoform expression was confirmed by western blot analysis on T cell extracts.
(J:180016)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pip5k1c Mutation: |
41 strains or lines available
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Original: |
J:164732 Wernimont SA, et al., PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells. J Immunol. 2010 Oct 15;185(8):4714-23 |
All: |
4 reference(s) |
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