Sh2d3c^tm1Ebp
Targeted Allele Detail

Summary

• Symbol: Sh2d3c^tm1Ebp
• Name: SH2 domain containing 3C; targeted mutation 1, Elena Pasquale
• MGI ID: MGI:4838036
• Synonyms: Shep1^flox
• Gene: Sh2d3c Location: Chr2:32611072-32645008 bp, + strand Genetic Position: Chr2, 22.09 cM, cytoband B
• Alliance: Sh2d3c^tm1Ebp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165694
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• A loxP site was inserted upstream of exon 7 and an FRT flanked neo cassette with a 3' loxP site. (J:165694)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sh2d3c Mutation: 31 strains or lines available

References

• Original: J:165694 Roselli S, et al., The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas. Cell Signal. 2010 Nov;22(11):1745-52
• All: 3 reference(s)