Fcrlb^tm1Pdb
Targeted Allele Detail

Summary

• Symbol: Fcrlb^tm1Pdb
• Name: Fc receptor-like B; targeted mutation 1, Peter D Burrows
• MGI ID: MGI:4838081
• Gene: Fcrlb Location: Chr1:170734842-170740510 bp, - strand Genetic Position: Chr1, 77.56 cM
• Alliance: Fcrlb^tm1Pdb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165408
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1, 2 and a portion of 3 along with a 2-kb promoter region were replaced with the neomycin gene by homologous recombination. (J:165408)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcrlb Mutation: 24 strains or lines available

References

• Original: J:165408 Masuda K, et al., Defining the immunological phenotype of Fc receptor-like B (FCRLB) deficient mice: Confounding role of the inhibitory FcgammaRIIb. Cell Immunol. 2010;266(1):24-31
• All: 1 reference(s)