Ccn2^tm2Mae
Targeted Allele Detail

Summary

• Symbol: Ccn2^tm2Mae
• Name: cellular communication network factor 2; targeted mutation 2, Nobuyo Maeda
• MGI ID: MGI:4838152
• Synonyms: Ctgf-Lo
• Gene: Ccn2 Location: Chr10:24471340-24474581 bp, + strand Genetic Position: Chr10, 11.84 cM, cytoband A3-B1
• Alliance: Ccn2^tm2Mae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165111
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous 3' UTR sequence was replaced with a cassette composed of a loxP site followed by the 3' UTR of the Fos gene, followed by the neomycin gene, a second loxP site and finally, the 3' UTR of the bovine growth hormone gene. The modified allele expresses the gene at lower levels whereas, after cre excision of the first 3'UTR and the neo cassette, the endogenous gene is over expressed. (J:165111)

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccn2 Mutation: 29 strains or lines available

References

• Original: J:165111 Doherty HE, et al., A mouse strain where basal connective tissue growth factor gene expression can be switched from low to high. PLoS One. 2010;5(9):e12909
• All: 2 reference(s)