Rr156^tm6.1Cog
Targeted Allele Detail

Summary

• Symbol: Rr156^tm6.1Cog
• Name: regulatory region 156; targeted mutation 6.1, Michel Cogne
• MGI ID: MGI:4838169
• Synonyms: delta hs4, Igh^tm6.1Cog
• Gene: Rr156 Location: Chr12:113191890-113191986 bp Genetic Position: Chr12, Syntenic
• Alliance: Rr156^tm6.1Cog page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165617
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site flanked neomycin resistance gene cassette replaced the most 3' set of DNAse I hypersensitive sequences (hs4) in the 3' regulatory region of the Igh gene. Subsequent Cre-mediated excision removed the selection cassette. (J:165617)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr156 Mutation: 0 strains or lines available

References

• Original: J:165617 Vincent-Fabert C, et al., Ig synthesis and class switching do not require the presence of the hs4 enhancer in the 3' IgH regulatory region. J Immunol. 2009 Jun 1;182(11):6926-32
• All: 1 reference(s)