Wnt4^tm1.2Boer
Targeted Allele Detail

Summary

• Symbol: Wnt4^tm1.2Boer
• Name: wingless-type MMTV integration site family, member 4; targeted mutation 1.2, Derek Boerboom
• MGI ID: MGI:4838181
• Synonyms: Wnt4^-
• Gene: Wnt4 Location: Chr4:137004946-137026812 bp, + strand Genetic Position: Chr4, 69.8 cM
• Alliance: Wnt4^tm1.2Boer page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162337
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic segment spanning exon 3 and exon 4 was removed by crossing Wnt4^tm1.1Boer with cre deleter mice. This is a null allele. (J:162337)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt4 Mutation: 21 strains or lines available

References

• Original: J:162337 Boyer A, et al., WNT4 is required for normal ovarian follicle development and female fertility. FASEB J. 2010 Aug;24(8):3010-25
• All: 2 reference(s)