Rims2^tm1Sse
Targeted Allele Detail

Summary

• Symbol: Rims2^tm1Sse
• Name: regulating synaptic membrane exocytosis 2; targeted mutation 1, Susumu Seino
• MGI ID: MGI:4838195
• Synonyms: Rim2alpha^-
• Gene: Rims2 Location: Chr15:39061681-39547768 bp, + strand Genetic Position: Chr15, 15.45 cM, cytoband C
• Alliance: Rims2^tm1Sse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163080
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on islet cell extracts. (J:163080)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rims2 Mutation: 250 strains or lines available

References

• Original: J:163080 Yasuda T, et al., Rim2alpha determines docking and priming States in insulin granule exocytosis. Cell Metab. 2010 Aug 4;12(2):117-29
• All: 1 reference(s)