Tlr9^M7Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr9^M7Btlr
• Name: toll-like receptor 9; mutation 7, Bruce Beutler
• MGI ID: MGI:4838258
• Synonyms: CpG11, Tlr9^CpG11
• Gene: Tlr9 Location: Chr9:106099797-106104075 bp, + strand Genetic Position: Chr9, 57.46 cM
• Alliance: Tlr9^M7Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, discovered in a screen of progeny of ethylnitrosourea (ENU) mutagenized mice for impaired responses to Toll-like receptor (TLR) ligands, has been identified as a T to C transition at nucleotide position 1181 of the transcript that is predicted to result in the replacement of serine by proline at amino acid position 359 of the protein (S359P), in the second leucine rich repeat. (J:165701)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr9 Mutation: 66 strains or lines available

References

• Original: J:165701 Huang H, et al., CpG11 is an allele of Tlr9 and causes Tlr9 signaling defects. MGI Direct Data Submission. 2010
• All: 42 reference(s)