Cdc20^tm1Jvd
Targeted Allele Detail

Summary

• Symbol: Cdc20^tm1Jvd
• Name: cell division cycle 20; targeted mutation 1, Jan M A van Deursen
• MGI ID: MGI:4838294
• Synonyms: Cdc20^H
• Gene: Cdc20 Location: Chr4:118290098-118294540 bp, - strand Genetic Position: Chr4, 54.61 cM
• Alliance: Cdc20^tm1Jvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165500
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette with stop codons in all three frames was inserted between exon 3 and 4. Reduced protein expression was confirmed by western blot analysis on testes and ovary extracts. This allele is hypomorphic. (J:165500)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdc20^tm1Jvd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdc20 Mutation: 30 strains or lines available

References

• Original: J:165500 Jin F, et al., Cdc20 is critical for meiosis I and fertility of female mice. PLoS Genet. 2010;6(9)
• All: 2 reference(s)