Plcg2^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Plcg2^m1Btlr
• Name: phospholipase C, gamma 2; mutation 1, Bruce Beutler
• MGI ID: MGI:4838296
• Synonyms: Queen
• Gene: Plcg2 Location: Chr8:118225030-118361881 bp, + strand Genetic Position: Chr8, 64.26 cM
• Alliance: Plcg2^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation has been identified as a T to A transversion at nucleotide position 1232 of the transcript, in the 12th of the gene's 33 exons. It is predicted to result in replacement of isoleucine by arginine at amino acid position 346 of the protein (I346R), in the X-box catalytic domain. (J:165702)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plcg2 Mutation: 74 strains or lines available

References

• Original: J:165702 Arnold CN, et al., Queen is an allele of Plcg2 and causes a deficiency in T-independent antibody responses. MGI Direct Data Submission. 2010
• All: 2 reference(s)