Cfp^tm2.1Song
Targeted Allele Detail

Summary

• Symbol: Cfp^tm2.1Song
• Name: complement factor properdin; targeted mutation 2.1, Wen-Chao Song
• MGI ID: MGI:4838300
• Synonyms: Cfp^fl
• Gene: Cfp Location: ChrX:20791693-20797794 bp, - strand Genetic Position: ChrX, 16.44 cM, cytoband A3
• Alliance: Cfp^tm2.1Song page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165497
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was constructed where a loxP site was inserted upstream of exon 3, and a FRT flanked neomycin resistance cassette followed by a loxP site was inserted downstream of exon 5. Flp mediated recombination removed the neo cassette leaving exons 3 through 5 floxed. (J:165497)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfp Mutation: 5 strains or lines available

References

• Original: J:165497 Kimura Y, et al., Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury. J Clin Invest. 2010 Oct 1;120(10):3545-54
• All: 1 reference(s)