Spesp1^tm1Osb
Targeted Allele Detail

Summary

• Symbol: Spesp1^tm1Osb
• Name: sperm equatorial segment protein 1; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:4838302
• Synonyms: Spesp1^tm1Oka
• Gene: Spesp1 Location: Chr9:62178011-62189461 bp, - strand Genetic Position: Chr9, 33.65 cM
• Alliance: Spesp1^tm1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159611
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Part of exon 2 of the gene was replaced with neo resistant cassette. Western blot analysis confirmed the absence of proteins. This is a null allele. (J:159611)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spesp1 Mutation: 22 strains or lines available

References

• Original: J:159611 Fujihara Y, et al., Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse. J Cell Sci. 2010 May 1;123(Pt 9):1531-6
• All: 3 reference(s)