Kdm6b^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Kdm6b^tm1Aki
• Name: KDM1 lysine (K)-specific demethylase 6B; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:4838334
• Gene: Kdm6b Location: Chr11:69289334-69304501 bp, - strand Genetic Position: Chr11, 42.6 cM
• Alliance: Kdm6b^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164690
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 14 through 21 were replaced with a neo cassette. The absence of transcript expression after LPS stimulation of mouse embryonic fibroblasts by RT-PCR. (J:164690)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6b Mutation: 67 strains or lines available

References

• Original: J:164690 Satoh T, et al., The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol. 2010 Oct;11(10):936-44
• All: 5 reference(s)