Etv1^{tm1.1(cre/ERT2)Zjh}
Targeted Allele Detail

Summary

• Symbol: Etv1^{tm1.1(cre/ERT2)Zjh}
• Name: ets variant 1; targeted mutation 1.1, Z Josh Huang
• MGI ID: MGI:4838417
• Synonyms: ER81-CreER, Er81-CreER-KI, ER81-CreERT2, Etv1-CreER, Etv1-CreERT2
• Gene: Etv1 Location: Chr12:38829655-38920484 bp, + strand Genetic Position: Chr12, 17.99 cM
• Alliance: Etv1^{tm1.1(cre/ERT2)Zjh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151755
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6
• Project Collection: Neuroscience Blueprint cre

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Etv1^{tm1.1(cre/ERT2)Zjh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Etv1 (MGI:99254)

• Mutation details: A targeting vector was designed to insert a Cre/ERT2 fusion gene , an SV40 polyA signal, and an frt-flanked neo cassette into the initiation codon of the ets variant gene 1 locus (Etv1). This construct was electroporated into C57BL/6-derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts and chimeric mice were bred with white C57BL/6 mice (harboring the Tyrc-2J mutation) to originate the colony. Mutant mice were bred with Actin-FLPe mice (on a C57BL/6 congenic background) to remove the neo selection cassette. (J:151755)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Etv1 (mouse) Summary of all recombinase alleles driven by Etv1. Comparative matrix view of recombinase activities Alliance mouse Etv1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Etv1 Mutation: 44 strains or lines available

References

• Original: J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009
• All: 32 reference(s)