Stk39^tm1.2Slin
Targeted Allele Detail

Summary

• Symbol: Stk39^tm1.2Slin
• Name: serine/threonine kinase 39; targeted mutation 1.2, Shih-Hua Lin
• MGI ID: MGI:4838422
• Gene: Stk39 Location: Chr2:68040789-68302381 bp, - strand Genetic Position: Chr2, 39.53 cM, cytoband C3
• Alliance: Stk39^tm1.2Slin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165706
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: One loxP site was inserted just 5' of exon 9 and an FRT flanked neomycin selection cassette was placed in intron 10 followed by a second loxP site. The selection cassette was subsequently excised from properly targeted ES cells usin flp recombinase, leaving exons 9 and 10 flanked by loxP sites. Mice were then crossed to transgenic mice expressing Tg(CAG-cre)13Miya to delete exons 9 and 10. (J:165706)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk39 Mutation: 42 strains or lines available

References

• Original: J:165706 Yang SS, et al., SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. J Am Soc Nephrol. 2010 Nov;21(11):1868-77
• All: 7 reference(s)