Myh9^tm5Rsad
Targeted Allele Detail

Summary

• Symbol: Myh9^tm5Rsad
• Name: myosin, heavy polypeptide 9, non-muscle; targeted mutation 5, Robert S Adelstein
• MGI ID: MGI:4838521
• Synonyms: Myh9^flox, NMII-Aflox
• Gene: Myh9 Location: Chr15:77644788-77726315 bp, - strand Genetic Position: Chr15, 36.81 cM
• Alliance: Myh9^tm5Rsad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164684
• Parent Cell Line: CMT-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a neo cassette with a 3' loxP site was inserted downstream of exon 3. (J:164684)

Expression

In Mice Carrying this Mutation:	66 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myh9 Mutation: 219 strains or lines available

References

• Original: J:164684 Jacobelli J, et al., Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat Immunol. 2010 Oct;11(10):953-61
• All: 32 reference(s)