Nox4tm1.1Ams
Targeted Allele Detail
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Symbol: |
Nox4tm1.1Ams |
Name: |
NADPH oxidase 4; targeted mutation 1.1, Ajay M Shah |
MGI ID: |
MGI:4838549 |
Gene: |
Nox4 Location: Chr7:86895304-87047918 bp, + strand Genetic Position: Chr7, 48.96 cM
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Alliance: |
Nox4tm1.1Ams page
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Germline Transmission: |
Earliest citation of germline transmission:
J:165541
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 1 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 2 via homologous recombination. Recombinase mediated recombination removed exons 1 and 2 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the hearts and kidneys of homozygous mice.
(J:165541)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Nox4 Mutation: |
68 strains or lines available
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Original: |
J:165541 Zhang M, et al., NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18121-6 |
All: |
17 reference(s) |
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