About   Help   FAQ
Nox4tm1.1Ams
Targeted Allele Detail
Summary
Symbol: Nox4tm1.1Ams
Name: NADPH oxidase 4; targeted mutation 1.1, Ajay M Shah
MGI ID: MGI:4838549
Gene: Nox4  Location: Chr7:86895304-87047918 bp, + strand  Genetic Position: Chr7, 48.96 cM
Alliance: Nox4tm1.1Ams page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:165541
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 2 via homologous recombination. Recombinase mediated recombination removed exons 1 and 2 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the hearts and kidneys of homozygous mice. (J:165541)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nox4 Mutation:  68 strains or lines available
References
Original:  J:165541 Zhang M, et al., NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18121-6
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory