Cxcl12tm3.1(HBEGF/EGFP)Tng
Targeted Allele Detail
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Symbol: |
Cxcl12tm3.1(HBEGF/EGFP)Tng |
Name: |
C-X-C motif chemokine ligand 12; targeted mutation 3.1, Takashi Nagasawa |
MGI ID: |
MGI:4838646 |
Synonyms: |
CXCL12-DTR-GFP |
Gene: |
Cxcl12 Location: Chr6:117145496-117158328 bp, + strand Genetic Position: Chr6, 54.81 cM, cytoband F1
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Alliance: |
Cxcl12tm3.1(HBEGF/EGFP)Tng page
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Germline Transmission: |
Earliest citation of germline transmission:
J:164657
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Inserted expressed sequence, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Cxcl12tm3.1(HBEGF/EGFP)Tng expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
HBEGF (1839) |
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Mutation details: The coding region of exon 1 was replaced with human HBEGF (Diphtheria toxin receptor) fused to EGFP and a floxed neo cassette. Cre mediated recombination removed the neo cassette. This allele allows for conditional ablation of Cxcl12-expressing cells following treatment with Diphtheria toxin.
(J:164657)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cxcl12 Mutation: |
25 strains or lines available
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Original: |
J:164657 Omatsu Y, et al., The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity. 2010 Sep 24;33(3):387-99 |
All: |
1 reference(s) |
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