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Cxcl12tm3.1(HBEGF/EGFP)Tng
Targeted Allele Detail
Summary
Symbol: Cxcl12tm3.1(HBEGF/EGFP)Tng
Name: C-X-C motif chemokine ligand 12; targeted mutation 3.1, Takashi Nagasawa
MGI ID: MGI:4838646
Synonyms: CXCL12-DTR-GFP
Gene: Cxcl12  Location: Chr6:117145496-117158328 bp, + strand  Genetic Position: Chr6, 54.81 cM, cytoband F1
Alliance: Cxcl12tm3.1(HBEGF/EGFP)Tng page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:164657
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Cxcl12tm3.1(HBEGF/EGFP)Tng expresses 1 gene
 
Mutation detailsThe coding region of exon 1 was replaced with human HBEGF (Diphtheria toxin receptor) fused to EGFP and a floxed neo cassette. Cre mediated recombination removed the neo cassette. This allele allows for conditional ablation of Cxcl12-expressing cells following treatment with Diphtheria toxin. (J:164657)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cxcl12 Mutation:  25 strains or lines available
References
Original:  J:164657 Omatsu Y, et al., The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity. 2010 Sep 24;33(3):387-99
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory