Nkap^tm1.1Viss
Targeted Allele Detail

Summary

• Symbol: Nkap^tm1.1Viss
• Name: NFKB activating protein; targeted mutation 1.1, Virginia Shapiro
• MGI ID: MGI:4839023
• Synonyms: Nkap^fl
• Gene: Nkap Location: ChrX:36390448-36414399 bp, + strand Genetic Position: ChrX, 21.54 cM
• Alliance: Nkap^tm1.1Viss page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165961
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Flp mediated recombination removed the neo cassette leaving exons 3 and 4 floxed. (J:165961)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkap Mutation: 1 strain or line available

References

• Original: J:165961 Pajerowski AG, et al., NKAP is a transcriptional repressor of notch signaling and is required for T cell development. Immunity. 2009 May;30(5):696-707
• All: 8 reference(s)