Clec1b^tm1.1Ksi
Targeted Allele Detail

Summary

• Symbol: Clec1b^tm1.1Ksi
• Name: C-type lectin domain family 1, member b; targeted mutation 1.1, Katsue Suzuki-Inoue
• MGI ID: MGI:4839037
• Gene: Clec1b Location: Chr6:129374260-129382376 bp, + strand Genetic Position: Chr6, 63.3 cM, cytoband F3
• Alliance: Clec1b^tm1.1Ksi page

Lymphatic function is impaired in Clec1b^tm1.1Ksi/Clec1b^tm1.1Ksi embryos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165898
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Cre mediated recombination removed part of exon 1 while leaving the neo cassette intact. (J:165898)

Generation of the Clec1b^tm1Ksi and Clec1b^tm1.1Ksi alleles

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec1b Mutation: 17 strains or lines available

References

• Original: J:165898 Suzuki-Inoue K, et al., Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets. J Biol Chem. 2010 Aug 6;285(32):24494-507
• All: 4 reference(s)