Tox^tm1Kay
Targeted Allele Detail

Summary

• Symbol: Tox^tm1Kay
• Name: thymocyte selection-associated high mobility group box; targeted mutation 1, Jonathan Kaye
• MGI ID: MGI:4839072
• Gene: Tox Location: Chr4:6686353-6991557 bp, - strand Genetic Position: Chr4, 3.04 cM
• Alliance: Tox^tm1Kay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164687
• Parent Cell Line: CMTI-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted downstream of exon 1 and an additional loxP site was inserted upstream of exon 1. After transient cre-expression cells were selected for elimination of the selectable marker cassettes but maintenance of loxP-flanked exon 1. (J:131287, J:164687)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tox Mutation: 39 strains or lines available

References

• Original: J:131287 Aliahmad P, et al., Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med. 2008 Jan 21;205(1):245-56
• All: 4 reference(s)