Rapgef2^tm1.2Hous
Targeted Allele Detail

Summary

• Symbol: Rapgef2^tm1.2Hous
• Name: Rap guanine nucleotide exchange factor (GEF) 2; targeted mutation 1.2, Steven X Hou
• MGI ID: MGI:4839129
• Gene: Rapgef2 Location: Chr3:78969823-79193824 bp, - strand Genetic Position: Chr3, 34.91 cM
• Alliance: Rapgef2^tm1.2Hous page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165879
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed exon 18. The absence of transcript expression was confirmed by northern blot analysis and in situ hydridization of E10.5 embryos. (J:165879)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rapgef2 Mutation: 83 strains or lines available

References

• Original: J:165879 Satyanarayana A, et al., RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood. 2010 Oct 21;116(16):2921-31
• All: 1 reference(s)