Ccrl2^tm1Ssoz
Targeted Allele Detail

Summary

• Symbol: Ccrl2^tm1Ssoz
• Name: C-C motif chemokine receptor-like 2; targeted mutation 1, Silvano Sozzani
• MGI ID: MGI:4839219
• Gene: Ccrl2 Location: Chr9:110883902-110886586 bp, - strand Genetic Position: Chr9, 60.92 cM, cytoband F
• Alliance: Ccrl2^tm1Ssoz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165873
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame was replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR on immature and TNFalpha- or LPS-stimulated bone marrow-derived dendritic cells. (J:165873)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccrl2 Mutation: 18 strains or lines available

References

• Original: J:165873 Otero K, et al., Nonredundant role of CCRL2 in lung dendritic cell trafficking. Blood. 2010 Oct 21;116(16):2942-9
• All: 5 reference(s)