Pknox1^tm1Fbla
Targeted Allele Detail

Summary

• Symbol: Pknox1^tm1Fbla
• Name: Pbx/knotted 1 homeobox; targeted mutation 1, Francesco Blasi
• MGI ID: MGI:4839363
• Gene: Pknox1 Location: Chr17:31783708-31826667 bp, + strand Genetic Position: Chr17, 16.78 cM, cytoband B-C
• Alliance: Pknox1^tm1Fbla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165811
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 7 and 8 were replaced with a splice acceptor beta-geo cassette. The absence of protein expression was confirmed by western blot analysis on embryonic stem cell extracts. (J:165811)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pknox1 Mutation: 90 strains or lines available

References

• Original: J:165811 Fernandez-Diaz LC, et al., The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells. Development. 2010 Oct;137(20):3393-403
• All: 2 reference(s)