Med12^tm1Hsch
Targeted Allele Detail

Summary

• Symbol: Med12^tm1Hsch
• Name: mediator complex subunit 12; targeted mutation 1, Heinrich Schrewe
• MGI ID: MGI:4839484
• Synonyms: Med12^hypo
• Gene: Med12 Location: ChrX:100317636-100341071 bp, + strand Genetic Position: ChrX, 43.91 cM, cytoband C2
• Alliance: Med12^tm1Hsch page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:166040
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: One loxP site was inserted in the 5'UTR of exon 1 while a second loxP site, followed by an FRT flanked neomycin cassette in reverse orientation, was inserted in intron 7. Gene expression was reduced 90%. (J:166040)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Med12 Mutation: 6 strains or lines available

References

• Original: J:166040 Rocha PP, et al., Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling. Development. 2010 Aug;137(16):2723-31
• All: 1 reference(s)