Tg(GZMB-Tax)#Lera
Transgene Detail

Summary

• Symbol: Tg(GZMB-Tax)#Lera
• Name: transgene insertion, Lee Ratner
• MGI ID: MGI:4839487
• Synonyms: GzmB Pr-Tax-HTLV-LTR, HTLV-1-Tax
• Transgene: Tg(GZMB-Tax)#Lera Location: unknown
• Alliance: Tg(GZMB-Tax)#Lera page

Increased osteolytic lesion formation and enhanced osteoclast activity in Ifngr1^tm1Agt/Ifngr1^tm1Agt Tg(GZMB-Tax)#Lera/0 mice

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The human GZMB promoter drives T cell expression of the Human T-cell leukemia virus type I (HTLV-I) regulatory protein Tax. Several lines were generated (lines F8, m259, m192, m191, m127, f137, m143, f6, and f243). No line number is designated by #. (J:129466)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(GZMB-Tax)#Lera

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:129466 Grossman WJ, et al., Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1057-61
• All: 7 reference(s)