Epo^tm1Knni
Targeted Allele Detail

Summary

• Symbol: Epo^tm1Knni
• Name: erythropoietin; targeted mutation 1, Knut Niss
• MGI ID: MGI:4839526
• Gene: Epo Location: Chr5:137481282-137484078 bp, - strand Genetic Position: Chr5, 76.5 cM, cytoband G
• Alliance: Epo^tm1Knni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165479
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site followed by a neomycin resistance cassette was inserted within intron 1 and a second loxP site in intron 4 by homologous recombination. (J:165479)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epo Mutation: 31 strains or lines available

References

• Original: J:165479 Zeigler BM, et al., A mouse model for an erythropoietin-deficiency anemia. Dis Model Mech. 2010 Nov-Dec;3(11-12):763-72
• All: 7 reference(s)