Myh4^arl
Chemically induced Allele Detail

Summary

• Symbol: Myh4^arl
• Name: myosin, heavy polypeptide 4, skeletal muscle; ariel
• MGI ID: MGI:4839531
• Synonyms: Myh4^L342Q
• Gene: Myh4 Location: Chr11:67128855-67151272 bp, + strand Genetic Position: Chr11, 40.59 cM
• Alliance: Myh4^arl page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation has been identified as a T to A transversion that is predicted to result in replacement of leucine by glutamine at amino acid position 342 of the myosin IIb (MYH4) motor domain (L342Q). (J:181892)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh4 Mutation: 95 strains or lines available

References

• Original: J:181892 Kurapati R, et al., Myofibrillar myopathy caused by a mutation in the motor domain of mouse MyHC IIb. Hum Mol Genet. 2012 Apr 15;21(8):1706-24
• All: 2 reference(s)