Tg(Prnp-TARDBP)4Jlel
Transgene Detail

Summary

• Symbol: Tg(Prnp-TARDBP)4Jlel
• Name: transgene insertion 4, Jeffrey L Elliott
• MGI ID: MGI:4839645
• Synonyms: WT TDP-43 line 4
• Transgene: Tg(Prnp-TARDBP)4Jlel Location: unknown
• Alliance: Tg(Prnp-TARDBP)4Jlel page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-TARDBP)4Jlel expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TARDBP (23435)

  Tardbp

  (MGI:2387629)

• Mutation details: The mouse promoter drives neuronal expression of the wild-type human cDNA. Several lines were established (including 4, 13, and 21). (J:165985)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:165985 Stallings NR, et al., Progressive motor weakness in transgenic mice expressing human TDP-43. Neurobiol Dis. 2010 Nov;40(2):404-14
• All: 2 reference(s)