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Ago2tm1.1Tara
Targeted Allele Detail
Summary
Symbol: Ago2tm1.1Tara
Name: argonaute RISC catalytic subunit 2; targeted mutation 1.1, Alexander Tarakhovsky
MGI ID: MGI:4839762
Synonyms: Ago2fl
Gene: Ago2  Location: Chr15:72967693-73056777 bp, - strand  Genetic Position: Chr15, 33.92 cM
Alliance: Ago2tm1.1Tara page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:165967
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neo cassette with a loxP site was inserted downstream of exon 11 and an additional loxP site was inserted btween exon 8 and 9. Flp-mediated recombination removed the neo cassette leaving exons 9 through 11 floxed. (J:165967)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ago2 Mutation:  56 strains or lines available
References
Original:  J:165967 O'Carroll D, et al., A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev. 2007 Aug 15;21(16):1999-2004
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory