Ago2^tm1.1Tara
Targeted Allele Detail

Summary

• Symbol: Ago2^tm1.1Tara
• Name: argonaute RISC catalytic subunit 2; targeted mutation 1.1, Alexander Tarakhovsky
• MGI ID: MGI:4839762
• Synonyms: Ago2^fl
• Gene: Ago2 Location: Chr15:72967693-73056777 bp, - strand Genetic Position: Chr15, 33.92 cM
• Alliance: Ago2^tm1.1Tara page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165967
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a loxP site was inserted downstream of exon 11 and an additional loxP site was inserted btween exon 8 and 9. Flp-mediated recombination removed the neo cassette leaving exons 9 through 11 floxed. (J:165967)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ago2 Mutation: 56 strains or lines available

References

• Original: J:165967 O'Carroll D, et al., A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev. 2007 Aug 15;21(16):1999-2004
• All: 18 reference(s)