Tg(Thy1-APPSwe)71Jgr
Transgene Detail

Summary

• Symbol: Tg(Thy1-APPSwe)71Jgr
• Name: transgene insertion 71, J Richards
• MGI ID: MGI:4839764
• Transgene: Tg(Thy1-APPSwe)71Jgr Location: unknown
• Alliance: Tg(Thy1-APPSwe)71Jgr page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APPSwe)71Jgr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: The construct contains a Thy1 promoter driving expression of the human APP with the Swedish familial Alzheimer disease mutations (K670N, M671L). Line 30 was generated. (J:88193)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:88193 Richards JG, et al., PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation. J Neurosci. 2003 Oct 1;23(26):8989-9003
• All: 7 reference(s)